Table 2.

Antifungal activities of fluconazole and itraconazole against BSIs of Candida spp. from three geographic regions

CountryNo. of isolatesAntifungal agentMIC (μg/ml)% Ra
Range50%90%
United States203Fluconazole0.12–>1280.5162.5
Itraconazole0.015–>8.00.121.011.3
Canada61Fluconazole0.12–1280.58.01.6
Itraconazole0.015–0.50.120.253.3
South America42Fluconazole0.12–>1280.54.02.4
Itraconazole0.015–8.00.120.252.4
All306Fluconazole0.12–>1280.58.02.3
Itraconazole0.015–>8.00.120.58.5
  • a % R, percent resistant by using the interpretive breakpoint criteria of NCCLS (5): fluconazole resistance, ≥64 μg/ml; itraconazole resistance, ≥1.0 μg/ml.