Table 3.

In vitro susceptibilities of BSIs of Candidaspp. tested to fluconazole and itraconazole

SpeciesNo. of isolatesAntifungal agentMIC (μg/ml)% Ra
Range50%90%
C. albicans 163Fluconazole0.12–>1280.251.00.6
Itraconazole0.015–>8.00.060.120.6
C. glabrata 46Fluconazole1.0–>1288.0328.7
Itraconazole0.12–>8.00.52.036.9
C. parapsilosis 48Fluconazole0.12–4.01.02.00
Itraconazole0.015–0.50.120.250
C. tropicalis 24Fluconazole0.25–4.00.52.00
Itraconazole0.03–1.00.120.54.2
C. krusei 6Fluconazole32–6432100b
Itraconazole0.12–2.01.066.6
Candidaspp.c 19Fluconazole0.25–162.0160
Itraconazole0.03–2.00.251.015.8
  • a % R, percent resistant by using interpretive breakpoint criteria of the NCCLS (5): fluconazole resistance, ≥64 μg/ml; itraconazole resistance, ≥1.0 μg/ml.

  • b Isolates of C. krusei are considered resistant to fluconazole, irrespective of the MIC.

  • c Includes C. guilliermondii (2 isolates) and Candida spp. (17 isolates).