Table 2.

Sensitivity, specificity, NPV, and PPV of the rDNA LPS ELISA, MIF assay, and PCR for determination of acute C. pneumoniae infections in patients with CAP requiring admission

Gold standardNo. (%) of patients positiveTest evaluatedSensitivity (%)Specificity (%)NPV (%)PPV (%)
MIF assay15 (9.6)ELISA80.094.397.860.0
PCR46.783.093.622.6
Expanded gold standard 1a 39 (25.0)MIF38.5100.083.0100.0
ELISA35.994.981.670.0
PCR79.5100.093.6100.0
Expanded gold standard 2b 12 (7.7)MIF100.097.9100.080.0
ELISA100.094.4100.060.0
PCR41.781.994.416.1
Expanded gold standard 3c 23 (14.7)MIF65.2100.094.3100.0
ELISA87.0100.097.8100.0
PCR39.183.588.829.0
  • a PCR and culture positive and/or MIF assay results indicating acute C. pneumoniae infection.

  • b MIF assay and rDNA LPS ELISA results indicating acute C. pneumoniae infection.

  • c MIF assay and/or rDNA LPS ELISA results indicating acute C. pneumoniae infection.