Table 2.

Susceptibilities of 104 selected pathogenic yeasts to SCH56592, MK-0991, and LY303366 as determined by a spectrophotometric procedure

Fungus (no. tested)Antifungal agentMIC range (μg/ml)MIC50 (μg/ml)MIC90 (μg/ml)MFC range (μg/ml)MFC90 (μg/ml)
C. albicans(10)aSCH565920.06–1.0 (>16)b0.51.0NDcNDc
MK-09910.25–20.51.00.5–>162
LY303366<0.03–0.250.060.250.25–41.0
C. albicans(10)dSCH56592<0.03–0.06 (>16)<0.03<0.03NDND
MK-09910.25–20.51.00.25–1.01.0
LY303366<0.03–0.25 (<0.03)0.060.060.25–1.00.5
C. glabrata(12)SCH56592<0.03–41.04>16≥16
MK-09910.5–20.51.01–42
LY3033660.06–0.250.120.250.12–1.00.5
C. guilliermondii(8)SCH56592<0.03–0.25 (0.06–4)0.25NDe4–>16ND
MK-0991>16 (0.5–8)2NDNDND
LY3033660.25–42ND4–8ND
C. krusei(13)SCH565920.5–1.01.01.01.0–21.0
MK-09910.5–41.021.0–22
LY3033660.12–1.0 (<0.03–0.5)0.51.00.25–1.01.0
C. lusitaniae(12)SCH56592<0.03–0.25 (<0.03–1.0)0.060.060.06–40.25
MK-09911.0–41.021.0–41.0
LY3033660.25–2 (0.06–2)1.021.0–22
C. parapsilosis(12)SCH595920.06–0.5 (0.06–>16)0.250.51.0–>168
MK-09910.5–2 (2–4)1.021.0–>162
LY3033660.5–2221.0–44
C. tropicalis(12)SCH565920.06–8 (>16)0.250.25NDND
MK-09910.5–2 (<0.03–2)1.01.00.5–1.01.0
LY3033660.12–0.5 (<0.03–0.2)0.250.50.12–1.01.0
C. neoformans(10)SCH565920.25–0.50.250.250.25–0.50.5
MK-099116–>16>16>16NDND
LY303366>16>16>6NDND
T. beigelii(5)SCH565920.12–1.01.0ND0.5–>16ND
MK-099116–>16>16ND>16ND
LY303366>16>16NDNDND
Total (104)
  • a Fluconazole MIC, >16 μg/ml; itraconazole MIC, 0.06 to >8 μg/ml.

  • b Values in parentheses are MIC-0 (SCH56592) and MIC-2 (other agents) endpoints.

  • c For MFC columns, ND indicates not done.

  • d Fluconazole MIC, ≤1.0 μg/ml; itraconazole MIC, <0.03 to 0.06 μg/ml.

  • e For the MIC90 column, ND indicates not obtained.