Table 4.

Summaries of published MIC data for four antifungal agents and for the three investigational agents from this studya

SpeciesAntifungal agentMIC50 (μg/ml)MIC90 (μg/ml)Geometric mean MIC (μg/ml)
Yeasts
Candidaspp.Amphotericin B1–2
Fluconazole2–64
Itraconazole0.25–2
Voriconazole0.06–4
SCH56592<0.03–4
MK-09911.0–2
LY3033660.06–2
Cryptococcus neoformansAmphotericin B1.0
Fluconazole16
Itraconazole1.0
Voriconazole0.12
SCH565920.25
MK-0991>16
LY303366>16
Trichosporon beigeliiAmphotericin B2
Fluconazole2
Itraconazole0.25
Voriconazole<0.03
SCH565921.0
MK-0991>16
LY303366>16
Opportunistic filamentous fungi
Aspergillus spp.Amphotericin B1.0–1.07
Itraconazole0.1–0.24
Voriconazole0.29–0.57
SCH 565920.1–0.13
MK-09910.5–2.15
LY3033660.06–0.08
Bipolaris spp.Amphotericin B0.65
Itraconazole0.06
Voriconazole0.33
SCH565920.14
MK-09911.7
LY3033662.7
Fusarium spp.Amphotericin B1.31–2
Itraconazole8
Voriconazole4–10.5
SCH565924.16–>16
MK-0991>16
LY303366>16
Pseudallescheria boydiiAmphotericin B2.6
Itraconazole0.76
Voriconazole0.33
SCH565921.0
MK-09911.3
LY3033662.5
Rhizopus arrhizusAmphotericin B0.57
Itraconazole0.43
Voriconazole18.37
SCH565922
MK-0991>16
LY303366>16
Dimorphic fungi
Blastomyces dermatitidisAmphotericin B0.14
Itraconazole0.06
Voriconazole0.1
SCH565920.05
MK-09912
LY3033664
Histoplasma capsulatumAmphotericin B0.42
Itraconazole0.06
Voriconazole0.06
SCH565920.04
MK-09911.3
LY3033663.6
Sporothrix schenckiiAmphotericin B1.5
Itraconazole0.5
Voriconazole16
SCH565920.7
MK-09915.4
LY3033663.9
  • a Data for amphotericin B, fluconazole, itraconazole, and another new triazole, voriconazole, have been published previously (5).