Table 2.

Susceptibility in antibiotic medium 3 brotha

IsolateNPutative statusbMIC (μg/ml)c
48 h72 h
RangeGeo MModeRangeGeo MMode
CN 129S0.125–0.250.190.250.125–0.50.330.5
CN 227S0.0625–0.250.190.250.125–10.350.25
CN 327S0.125–0.50.260.250.125–20.420.5
CN 428S0.125–0.250.190.250.25–0.50.350.25
CN 529S0.0625–0.250.10.06250.0625–0.50.250.25
CN 628S0.0625–0.250.20.250.25–10.340.25
CN 729S0.0625–0.250.180.250.125–10.360.5
CN 938S0.0625–0.250.180.250.25–10.380.5
CN 1220S0.125–0.250.140.1250.125–0.250.180.25
CN 844R0.5–20.911.0–8.01.62
CN 1020R1.0–2.01.111.0–2.01.181
CN 1120R1.0–2.0111.0–2.01.031
Clinical72S0.0625–0.250.170.250.125–0.50.250.25
  • a Eighty-four C. neoformansisolates were tested by the microdilution methodology in broth in antibiotic medium 3. Isolates CN 1 to CN 12 were tested the indicated number of times (N), while the 72 clinical isolates were tested once each. MICs were determined after 48 and 72 h of incubation.

  • b S, susceptible; R, resistant.

  • c Range, range of MICs; Geo M, geometric mean MIC; Mode, modal MIC.