Table 1.

Susceptibilities of 83 opportunistic filamentous and dimorphic fungi to SCH56592, MK-0991, and LY303366a

Fungus (no. tested)Antifungal agentMIC range (μg/ml)Geometric mean MIC (μg/ml)MFC range (μg/ml)
Opportunistic filamentous fungi
Acremonium strictum(1)SCH565920.06NDb>16
MK-09910.5ND>16
LY303366>16NDNDc
Aspergillus flavus(11)SCH565920.03–0.120.100.25–2
MK-09910.50.5ND
LY303366<0.03–0.120.08ND
Aspergillus fumigatus(13)dSCH56592<0.03–1.00.130.25–>16
MK-09910.5–>162.15ND
LY3033660.060.06ND
Aspergillus terreus(2)SCH59592<0.03–0.5ND1.0
MK-09910.5NDND
LY303366<0.03NDND
Bipolaris spp.e(6)SCH565920.06–0.250.140.5–4
MK-09911.0–21.7ND
LY3033661.0–42.7ND
Cladophialophora bantiana(5)SCH56592<0.03–0.060.050.06–0.5
MK-09912–83.68–>16
LY3033661.0–428–>16
Fusarium oxysporum(6)SCH565921–>164.162–>16
MK-0991>16>16ND
LY30336616–>16>16ND
Fusarium solani(6)SCH56592>16>16ND
MK-099116–>16>16ND
LY303366>16>16ND
Phialophora spp.f(5)SCH565920.06–1.00.42–>16
MK-09911.0–162.8>16
LY3033661.0–>169>16
Pseudallescheria boydii(6)SCH565920.5–21.0>16
MK-09910.5–41.3>16
LY3033662–42.5>16
Rhizopus arrhizus(5)SCH56592222–16
MK-0991>16>16ND
LY303366>16>16ND
Scedosporium prolificans(2)SCH56592>16NDND
MK-09914–8ND>16
LY3033664NDND
Dimorphic fungi
Blastomyces dermatitidis(5)SCH56592<0.03–0.060.052–16
MK-09910.5–82ND
LY3033662–84ND
Histoplasma capsulatum(5)SCH56592<0.03–0.060.040.5–2
MK-09910.5–41.3ND
LY3033662–43.6ND
Sporothrix schenckii(5)SCH565920.12–1.00.71–4
MK-09911.0–>165.4ND
LY3033660.25–>163.9ND
Total (83)
  • a Visual MICs-2 correspond to prominent growth inhibition (approximately ≤50% of that of the growth control).

  • b For the geometric mean MIC column, ND indicates not obtained.

  • c For the MFC range column, ND indicates not done.

  • d The set included two isolates resistant to itraconazole (MICs, >8 μg/ml).

  • e Bipolaris hawaiiensis and Bipolaris spicifera.

  • f Phialophora parasitica, Phialophora repens, and Phialophora verrucosa.