Table 4.

Susceptibility on RPMI 1640 agara

IsolateNPutative statusbMIC (μg/ml)c
48 h72 h
RangeGeo MModeRangeGeo MMode
CN 13S0.19–0.250.230.250.380.380.38
CN 23S0.1250.1250.1250.250.250.25
CN 33S0.19–0.1250.140.125 0.19–0.380.260.19
CN 43S0.094–0.250.140.0940.250.250.25
CN 53S0.064–0.0940.070.0640.190.190.19
CN 63S0.125–0.190.160.19 0.19–0.250.230.25
CN 73S0.094–0.1250.110.1250.190.190.19
CN 93S0.1250.1250.1250.250.250.25
CN 123S0.1250.1250.1250.190.190.19
CN 83R2.0–4.02.82  4.0–6.0 5.26
CN 103R1.5–21.651.5  2.0–4.0 2.52
CN 113R2    22222
Clinical72S0.006–0.380.0860.0940.064–0.5 0.1620.19
  • a Each named Cryptococcusisolate was tested the indicated number of times by the E-test methodology in 2% glucose-supplemented RPMI 1640 agar. Isolates CN 1 to CN 12 were tested the indicated number of times (N), while the 72 clinical isolates were tested once each. MICs were determined after 48 and 72 h of incubation.

  • b S, susceptible; R, resistant.

  • c MIC range, range of MICs; Geo M, geometric mean MIC; Mode, modal MIC.