Sensitivity of CSF-FTA-ABS and CSF-TPPA for neurosyphilis diagnosis in the training data seta

Test% sensitivity (95% CI) for the following neurosyphilis definition:
Reactive CSF-VDRLDetection of T. pallidum in CSFNew vision or hearing loss
CSF-FTA-ABS98.3 (95.0–100.0)66.7 (52.9–80.4)77.5 (64.6–90.4)
CSF-TPPA95.0 (89.5–100.0)75.6 (63.0–88.1)77.5 (64.6–90.4)
CSF-VDRL48.9 (34.3–63.5)67.5 (53.0–82.0)
  • a CI, confidence interval; CSF, cerebrospinal fluid; CSF-FTA-ABS, CSF fluorescent treponemal antibody absorption test; CSF-TPPA, CSF Treponema pallidum particle agglutination assay; CSF-VDRL, CSF Venereal Disease Research Laboratory test. CSF-FTA-ABS results graded ≥2+ were considered reactive. CSF-TPPA was considered reactive if the titer was ≥1:80, the initial dilution tested.