TABLE 3

Specificity of CSF-TPPA cutoffs for neurosyphilis diagnosis in the training data seta

Test% specificity (95% CI) for the following neurosyphilis definition:
Reactive CSF-VDRLDetection of T. pallidum in CSFNew vision or hearing loss
CSF-TPPA titer of:
    ≥1:16075.6 (68.2–83.0)63.0 (55.2–70.8)63.4 (55.5–71.3)
    ≥1:32086.3 (80.4–92.2)73.3 (66.1–80.5)75.4 (68.3–82.5)
    ≥1:64093.9 (89.8–98.0)81.5 (75.2–87.8)85.2 (79.4–91.0)
CSF-VDRL74.0 (66.9–81.1)78.2 (71.4–85.0)
  • a CI, confidence interval; CSF, cerebrospinal fluid; CSF-TPPA, CSF Treponema pallidum particle agglutination assay; CSF-VDRL, CSF Venereal Disease Research Laboratory test.