Table 5.

Performance of broad-range bacterial PCR compared to culture results and clinical evaluation for various sample typesa

Sample typeNo. of samplesSensitivity (%)Specificity (%)PPVb (%)NPVc(%)
Tissue biopsy specimen5910098.187.5100
Cerebrospinal fluid25063.299.692.397.1
Amniotic fluid33100100100100
Pleural fluid5460.098.075.096.0
Synovial fluid4610095.171.4100
Pus5068.496.892.983.3
All samples51574.298.788.596.6
  • a Sequencing failures for culture-negative samples were designated PCR contaminations.

  • b PPV, positive predictive value.

  • c NPV, negative predictive value.