Table 1.

Primary HHV-7 infection in British children: antibody responses and detection of viral DNA

Patient no.Age (mo)Day after onset of symptomsSerum or plasma
HHV-6 IgG titeraHHV-6 DNAHHV-7 IgG titeraHHV-7 DNA
Without ureaWith ureaWithout ureaWith urea
10174<8<8<8<8+
1116 NTb5128
41c<16<16NT51216NT
1688<8512128
112110<8<8<8<8
172c, d<16<16NT2,04864NT
206<8<81,02432
334<8<825664
340c<16<16NT512256NT
12133512256648+
15c8,1924,096NT8,19216NT
961,0242,0484,09632
119e512NTNT25664NT
  • a Those sera whose antibody titers were reduced eightfold or greater by urea are defined as having low-avidity antibody and the results are highlighted in bold. Those sera whose titers were reduced fourfold or less by urea are defined as having high-avidity antibody.

  • b NT, not tested.

  • c Saliva contained HHV-7 DNA but not HHV-6 DNA.

  • d Patient 11 presented with an encephalopathic Illness. HHV-7 seroconversion was picked up by chance in a convalescent-phase specimen.

  • e Saliva contained HHV-7 DNA and HHV-6 DNA.