Table 1.

Primary HHV-7 infection in British children: antibody responses and detection of viral DNA

Patient no.Age (mo)Day after onset of symptomsSerum or plasma
HHV-6 IgG titeraHHV-6 DNAHHV-7 IgG titeraHHV-7 DNA
Without ureaWith ureaWithout ureaWith urea
1116 NTb 512 8
41c <16<16NT 512 16 NT
172c,d <16<16NT 2,048 64 NT
206<8<8 1,024 32
340c <16<16NT512256NT
12133512256 64 8 +
15c 8,1924,096NT 8,192 16 NT
961,0242,048 4,096 32
119e 512NTNT25664NT
  • a Those sera whose antibody titers were reduced eightfold or greater by urea are defined as having low-avidity antibody and the results are highlighted in bold. Those sera whose titers were reduced fourfold or less by urea are defined as having high-avidity antibody.

  • b NT, not tested.

  • c Saliva contained HHV-7 DNA but not HHV-6 DNA.

  • d Patient 11 presented with an encephalopathic Illness. HHV-7 seroconversion was picked up by chance in a convalescent-phase specimen.

  • e Saliva contained HHV-7 DNA and HHV-6 DNA.