Table 2.

Penicillin G and clarithromycin resistance in pneumococcal isolates from 17 medical centersain Germany

TownNo. of isolatesRegionbPenicillin GClarithromycin
Ic(%)Rc (%)Ic(%)Rc (%)
Hamburg49N6.106.18.2
Osnabrück64N10.906.39.4
Plön22N4.64.64.69.1
Trier57C-W001.87.0
Wülfrath98C-W3.103.18.2
Bonn47C-W6.40021.3
Dillingen43C-W1409.311.6
Weiden41C-W9.84.904.9
Dortmund56C-W14.303.6012.5
Leverkusen109C-W5.505.58.3
Aachen61C-W3.3001.6
Bad Hersfeld66E6.1001.5
Chemnitz18E5.60011.1
Berlin I33E12.10015.2
Berlin II13E00015.4
Augsburg89S3.401.11.1
Stuttgart83S6.003.64.8
  • a Centers with less than 10 isolates (n = 2) were not evaluated.

  • b Centers were categorized in the following geographic regions: N, north Germany; C-W, central-western Germany; E, eastern Germany; S, southern Germany. For cumulative resistance data, see text.

  • c Breakpoints (I, R) according to NCCLS (8). Penicillin G: I, 0.1–1 mg/liter; R, ≥2 mg/liter. Clarithromycin: I, 0.5 mg/liter; R, ≥1 mg/liter.