Table 1.

Mutation frequencies for HSV

HSV type and isolateIsolates in clinical sampleLaboratory isolates
No. of PFU/ml with:Mutation frequencyIC50(μg/ml)No. of PFU/ml with:Mutation frequencyIC50 (μg/ml)
ACVNo ACVACVNo ACV
Type 1
 2926.0 × 102 3.5 × 106 1.7 × 10−4 1.391.0 × 104 3.3 × 107 3.0 × 10−4 0.75
 3051.1 × 105 1.9 × 108 5.7 × 10−4 1.072.7 × 107 3.6 × 1010 7.4 × 10−4 1.25
 3735.5 × 104 5.5 × 107 1.0 × 10−3 1.402.7 × 106 2.1 × 109 1.3 × 10−3 1.43
 5652.5 × 103 3.9 × 107 6.4 × 10−5 0.581.4 × 104 1.4 × 109 1.0 × 10−5 0.52
 8602.5 × 103 2.0 × 107 1.2 × 10−4 0.157.0 × 103 2.0 × 108 3.5 × 10−5 0.17
 10063.1 × 105 2.5 × 108 1.3 × 10−3 0.836.1 × 105 1.9 × 1010 3.3 × 10−5 0.75
 11595.5 × 102 1.8 × 105 3.1 × 10−3 1.442.8 × 106 6.3 × 108 4.5 × 10−3 1.03
 11898.8 × 105.0 × 104 1.8 × 10−3 1.033.3 × 105 1.8 × 109 1.8 × 10−4 1.10
 13353.8 × 101.4 × 105 2.7 × 10−4 0.797.5 × 102.5 × 104 3.0 × 10−3 0.81
 13561.9 × 103 3.4 × 107 5.6 × 10−5 0.822.3 × 107 2.3 × 1011 1.0 × 10−4 1.04
 13611.0 × 102 2.6 × 106 3.8 × 10−5 0.703.6 × 102 1.2 × 105 3.0 × 10−3 0.71
 13628.3 × 102 4.1 × 106 2.0 × 10−4 0.632.3 × 104 1.9 × 109 1.2 × 10−5 0.73
 14126.9 × 105 3.9 × 108 1.8 × 10−3 1.091.6 × 108 4.5 × 1010 3.5 × 10−3 0.80
 14221.1 × 104 1.1 × 108 1.0 × 10−4 0.531.8 × 106 2.4 × 109 7.3 × 10−4 0.73
 Mean7.5 × 10−4 0.8912.0 × 10−4 a 0.85b
 Standard error2.5 × 10−4 0.104.2 × 10−4 0.08
Type 2
 7274.0 × 108.0 × 104 5.0 × 10−4 0.841.2 × 106 2.8 × 109 4.2 × 10−4 0.77
 8004.0 × 108.0 × 104 5.0 × 10−4 0.691.4 × 103 1.0 × 106 1.4 × 10−3 0.93
 9891.2 × 104 2.6 × 106 4.6 × 10−3 2.381.8 × 104 1.9 × 107 9.5 × 10−4 1.77
 10413.8 × 102.1 × 104 1.8 × 10−3 0.885.3 × 102 5.0 × 105 1.1 × 10−3 1.16
 10716.0 × 105 6.6 × 108 9.2 × 10−4 0.765.1 × 103 1.6 × 106 3.2 × 10−3 0.83
 10816.1 × 105 2.9 × 108 2.1 × 10−3 1.193.6 × 106 1.4 × 1010 2.6 × 10−4 0.65
 12828.5 × 101.0 × 105 8.5 × 10−4 0.519.3 × 103 1.4 × 107 6.6 × 10−4 0.82
 12924.0 × 105.0 × 104 8.0 × 10−4 0.601.1 × 104 8.0 × 107 1.4 × 10−4 0.86
 13011.5 × 105 1.6 × 108 9.6 × 10−4 1.541.4 × 105 1.6 × 108 8.9 × 10−4 1.91
 13764.4 × 104 5.1 × 107 8.7 × 10−4 0.982.7 × 102 5.0 × 106 5.4 × 10−5 0.50
 14053.5 × 103 4.6 × 107 7.5 × 10−5 0.823.4 × 103 9.0 × 107 3.8 × 10−5 0.56
 15132.9 × 103 3.0 × 106 9.6 × 10−4 0.617.1 × 104 2.7 × 109 3.0 × 10−5 0.68
 15147.5 × 103 7.5 × 106 1.0 × 10−3 2.247.5 × 103 1.0 × 107 7.5 × 10−4 1.74
 15601.0 × 101.3 × 104 8.0 × 10−5 0.581.0 × 104 1.6 × 108 6.2 × 10−5 0.76
 16241.6 × 104 2.5 × 106 6.5 × 10−3 1.521.0 × 102 2.5 × 104 4.0 × 10−3 1.34
 Mean15.0 × 10−4 c 1.08d 9.3 × 10−4 e,f 1.02g, h
 Standard error4.6 × 10−4 0.153.0 × 10−4 0.12
  • a Mutation frequency laboratory versus clinical HSV type 1, P = 0.09 .

  • b IC50 for laboratory versus clinical HSV type 1, P = 0.27 .

  • c Mutation frequency for HSV type 1 versus HSV type 2 in a clinical sample, P = 0.08 .

  • d IC50 for HSV type 1 versus HSV type 2 in a clinical sample, P = 0.16 .

  • e Mutation frequency for laboratory versus clinical HSV type 2, P = 0.06 .

  • f Mutation frequency for HSV type 1 versus HSV type 2 laboratory isolate, P = 0.27 .

  • g IC50 for laboratory versus clinical HSV type 2, P = 0.27 .

  • h IC50 for HSV type 1 versus HSV type 2 laboratory isolate, P = 0.13 .