Table 1.

Mutation frequencies for HSV

HSV type and isolateIsolates in clinical sampleLaboratory isolates
No. of PFU/ml with:Mutation frequencyIC50(μg/ml)No. of PFU/ml with:Mutation frequencyIC50 (μg/ml)
ACVNo ACVACVNo ACV
Type 1
 2926.0 × 1023.5 × 1061.7 × 10−41.391.0 × 1043.3 × 1073.0 × 10−40.75
 3051.1 × 1051.9 × 1085.7 × 10−41.072.7 × 1073.6 × 10107.4 × 10−41.25
 3735.5 × 1045.5 × 1071.0 × 10−31.402.7 × 1062.1 × 1091.3 × 10−31.43
 5652.5 × 1033.9 × 1076.4 × 10−50.581.4 × 1041.4 × 1091.0 × 10−50.52
 8602.5 × 1032.0 × 1071.2 × 10−40.157.0 × 1032.0 × 1083.5 × 10−50.17
 10063.1 × 1052.5 × 1081.3 × 10−30.836.1 × 1051.9 × 10103.3 × 10−50.75
 11595.5 × 1021.8 × 1053.1 × 10−31.442.8 × 1066.3 × 1084.5 × 10−31.03
 11898.8 × 105.0 × 1041.8 × 10−31.033.3 × 1051.8 × 1091.8 × 10−41.10
 13353.8 × 101.4 × 1052.7 × 10−40.797.5 × 102.5 × 1043.0 × 10−30.81
 13561.9 × 1033.4 × 1075.6 × 10−50.822.3 × 1072.3 × 10111.0 × 10−41.04
 13611.0 × 1022.6 × 1063.8 × 10−50.703.6 × 1021.2 × 1053.0 × 10−30.71
 13628.3 × 1024.1 × 1062.0 × 10−40.632.3 × 1041.9 × 1091.2 × 10−50.73
 14126.9 × 1053.9 × 1081.8 × 10−31.091.6 × 1084.5 × 10103.5 × 10−30.80
 14221.1 × 1041.1 × 1081.0 × 10−40.531.8 × 1062.4 × 1097.3 × 10−40.73
 Mean7.5 × 10−40.8912.0 × 10−4a0.85b
 Standard error2.5 × 10−40.104.2 × 10−40.08
Type 2
 7274.0 × 108.0 × 1045.0 × 10−40.841.2 × 1062.8 × 1094.2 × 10−40.77
 8004.0 × 108.0 × 1045.0 × 10−40.691.4 × 1031.0 × 1061.4 × 10−30.93
 9891.2 × 1042.6 × 1064.6 × 10−32.381.8 × 1041.9 × 1079.5 × 10−41.77
 10413.8 × 102.1 × 1041.8 × 10−30.885.3 × 1025.0 × 1051.1 × 10−31.16
 10716.0 × 1056.6 × 1089.2 × 10−40.765.1 × 1031.6 × 1063.2 × 10−30.83
 10816.1 × 1052.9 × 1082.1 × 10−31.193.6 × 1061.4 × 10102.6 × 10−40.65
 12828.5 × 101.0 × 1058.5 × 10−40.519.3 × 1031.4 × 1076.6 × 10−40.82
 12924.0 × 105.0 × 1048.0 × 10−40.601.1 × 1048.0 × 1071.4 × 10−40.86
 13011.5 × 1051.6 × 1089.6 × 10−41.541.4 × 1051.6 × 1088.9 × 10−41.91
 13764.4 × 1045.1 × 1078.7 × 10−40.982.7 × 1025.0 × 1065.4 × 10−50.50
 14053.5 × 1034.6 × 1077.5 × 10−50.823.4 × 1039.0 × 1073.8 × 10−50.56
 15132.9 × 1033.0 × 1069.6 × 10−40.617.1 × 1042.7 × 1093.0 × 10−50.68
 15147.5 × 1037.5 × 1061.0 × 10−32.247.5 × 1031.0 × 1077.5 × 10−41.74
 15601.0 × 101.3 × 1048.0 × 10−50.581.0 × 1041.6 × 1086.2 × 10−50.76
 16241.6 × 1042.5 × 1066.5 × 10−31.521.0 × 1022.5 × 1044.0 × 10−31.34
 Mean15.0 × 10−4c1.08d9.3 × 10−4e, f1.02g, h
 Standard error4.6 × 10−40.153.0 × 10−40.12
  • a Mutation frequency laboratory versus clinical HSV type 1, P = 0.09 .

  • b IC50 for laboratory versus clinical HSV type 1, P = 0.27 .

  • c Mutation frequency for HSV type 1 versus HSV type 2 in a clinical sample, P = 0.08 .

  • d IC50 for HSV type 1 versus HSV type 2 in a clinical sample, P = 0.16 .

  • e Mutation frequency for laboratory versus clinical HSV type 2, P = 0.06 .

  • f Mutation frequency for HSV type 1 versus HSV type 2 laboratory isolate, P = 0.27 .

  • g IC50 for laboratory versus clinical HSV type 2, P = 0.27 .

  • h IC50 for HSV type 1 versus HSV type 2 laboratory isolate, P = 0.13 .