Table 2.

MICs by Etest of seven antimicrobial agents for M. abscessus reported by four separate laboratories

DrugMIC (μg/ml) for isolate:
180118021807
Mode (range)% AgreementaMode (range)% AgreementaMode (range)% Agreementa
Amikacin16 (4–256)88.9256 (16–256)52.816 (4–256)72.2
Cefoxitin64 (16–64)97.2512 (64–512)97.2512 (32–512)63.9
Ciprofloxacin32 (32)10032 (32)10032 (0.125–32)91.7
Clarithromycin0.25 (0.06–2)91.7128 (128)b 1000.125 (0.06–64)91.7
Doxycycline64 (64)10064 (64)10064 (64)100
Imipenem64 (8–64)88.964 (32–64)10064 (16–64)97.2
Trimethoprim-sulfamethoxazole64 (64)10064 (64)10064 (64)100
  • a Percent MICs in each 3-dilution range (mode ± log2).

  • b Strain contains 23S rRNA gene mutation at position 2058 or 2059 that confers high-level resistance to clarithromycin (11, 15).