TABLE 2

Sensitivity of CNS-TAC assays compared to IRTP assays using a CT of 40 as a cutoffa

Target and parameterIRTP assayTAC assay% Sensitivity (95% CI)
CMV
    No. positive75100 (59.0–100)
    Mean CT ± SD35.5 ± 2.833.0 ± 2.3
    Median CT (range)36 (30.7–38.9)33.2 (29.9–36)
Neisseria meningitidis
    No. positive55100 (47.8–100)
    Mean CT ± SD24.2 ± 1.923.16 ± 1.6
    Median CT (range)24.4 (21.5–26.7)23 (21.1–24.9)
EBV
    No. positive81080.0 (44.4–97.5)
    Mean CT ± SD34.9 ± 2.032.2 ± 1.1
    Median CT (range)35.5 (31.5–37.0)32.1 (29.8–34.0)
VZV
    No. positive1333.3 (0.8–90.6)
    Mean CT ± SD30.628.3 ± 3.5
    Median CT (range)29.0 (24.4–31.3)
Streptococcus pneumoniae
    No. positive5683.3 (35.9–99.6)
    Mean CT ± SD23.0 ± 3.222.4 ± 4.0
    Median CT (range)22.8 (18.8–27.5)22.3 (17.6–27.6)
Mumps virus
    No. positive1250.0 (1.3–98.7)
    Mean CT ± SD31.827.3 ± 6.2
    Median CT (range)27.3 (22.9–31.8)
Mycobacterium tuberculosis
    No. positive6785.7 (42.1–99.6)
    Mean CT ± SD33.4 ± 2.532.2 ± 4.0
    Median CT (range)33.1 (29.9–37.7)34.0 (24.8–36.8)
Haemophilus influenzae
    No. positive22100 (47.8–100)
    Mean CT ± SD22.1 ± 6.623.2 ± 5.6
    Median CT (range)22.1 (17.4–26.8)23.2 (19.2–27.2)
Acanthamoeba
    No. positive02
    Mean CT ± SD34.9 ± 3.2
    Median CT (range)34.1 (33.9–38.4)
  • a IRTP, individual real-time PCR; TAC, TaqMan array card; CI, confidence interval.