TABLE 4

Specificity of CSF-TPPA titer of ≥1:640 and CSF-VDRL for neurosyphilis diagnosis in the validation data seta

Test% specificity (95% CI) for the following neurosyphilis definition:
Reactive CSF-VDRLDetection of T. pallidum in CSFNew vision or hearing loss
CSF-TPPA titer of ≥1:64097.0 (95.2–98.8)93.8 (91.2–96.4)93.3 (90.4–96.2)
CSF-VDRL91.2 (88.1–94.2)90.2 (86.7–93.6)
  • a CI, confidence interval; CSF, cerebrospinal fluid; CSF-TPPA, CSF Treponema pallidum particle agglutination assay; CSF-VDRL, CSF Venereal Disease Research Laboratory test.