Table 3.

Distribution of differences in MICs for 181 molds and percent agreement within 3 dilutions for the E-test and the NCCLS M38-P method

Fungus (no. of isolates tested)Antifungal agentaIncubation time (h) or reading no.No. of isolates for which MICs determined by E-test differed from MICs determined by method by the following dilution:% Agreementb
>+2>+2+10−1−2>−2
A. flavus(16)A2443331275
481131131.2
I243553100
48745100
A. fumigatus(69)A2441416228297
48251582163.8
I24511172372190
4818122017274
A. nidulans(12)A2412241183.3
48524158.3
I241215283.3
482116283.3
A. niger(10)A24253100
4837100
I2419100
4819100
A. terreus(16)A2421531177
483444175
I241431492
4824321488
F. oxysporum(6)A2451NAc
486NA
I24231NA
486NA
F. solani(10)A2411222270
48611240
I2410100
4810100
P. lilacinus(4)A48–724NA
I48–72121NA
S. apiospermum(10)A48334100
72334100
I48343100
72343100
S. prolificans(5)A24
4814NA
I24
4814NA
T. longibrachiatum (5)A2432NA
4823NA
I245NA
485NA
Dematiaceous molds (18)dA4813352293.7
72134593.3
I4811327781.2
7213722283.3
All isolates (181)AReading 1141736423315687.7
Reading 257272240268167.9
IReading 172129632117592.7
Reading 2212641631511486
  • a A, amphotericin B; I, itraconazole.

  • b Percent agreement is the percentage of the MIC results obtained by the two methods that were within 3 dilutions.

  • c NA, not applicable (too few isolates).

  • d Isolates of C. bantiana needed 4 days of incubation.