Table 2.

M38-P MICs for 181 opportunistic molds determined by the E-test and the NCCLS M38-P methoda

Fungus (no. of isolates tested)Antifungal AgentbIncubation time (h)MIC (μg/ml) determined by:
E-testNCCLS M38-P method
RangeGeometric mean90%RangeGeometric Mean90%
A. flavus(16)A240.25–>83.3>8
480.5–>8>8>80.5–41.262
I240.06–0.250.140.25
480.12–1.00.250.50.03–0.250.110.25
A. fumigatus(69)A240.25–81.392
480.25–>85.2>80.25–41.21.0
I240.06–>80.842
480.12–>81.5740.03–>80.710.5
A. nidulans(12)A240.25–>81.52
480.5–>86.1>80.5–40.882
I240.06–0.250.120.25
480.12–1.00.150.50.06–0.250.160.25
A. niger(10)A240.5–1.00.751.0
481.01.01.00.5–1.00.71.0
I240.50.50.5
481.01.01.00.12–1.00.481.0
A. terreus(16)A240.25–42.134
480.25–82.8540.5–41.44
I240.01–0.50.180.5
480.03–0.50.190.50.03–0.50.140.25
F. oxysporum(6)A241.0–>8>8>8
481.0–>8>8>81.01.01.0
I244–>8>8>8
48>81.0–>8>8>8
F. solani(10)A240.12–>82.088
480.5–>8>8>80.5–41.624
I24>8
48>88–>8>8>8
P. lilacinus(4)A48–72>8>8
I48–722–>87>82–>85.7>8
S. apiospermum(10)A484–86.78
724–86.781–83.174
I480.25–0.50.40.5
720.25–0.50.40.50.25–1.00.851.0
S. prolificans(5)A48>88–>8>8>8
I48>84–>8>8>8
T. longibrachiatum(5)A240.5–1.00.831.0
481.0–42.220.5–20.870.5
I24>8
48>8>8
Dematiaceous molds (18)cA480.06–41.02
720.12–>82.7480.12–40.852
I480.01–0.120.060.12
720.01–0.50.130.250.06–20.370.5
  • a The NCCLS M38-P broth microdilution method has been described previously (22).

  • b A, amphotericin B; I, itraconazole

  • c This group included one to three isolates each of Bipolaris spp., C. bantiana, C. cladosporioides, D. constricta var. gallopava, P. parasiticum (P. parasitica), and W. dermatitidis.