Table 4.

Amino acid substitutions in HIV-2-infected patients exposed to protease inhibitors

SampleaAmino acid position in protease coding regionb
10 (L→I/R/V)20 (K→M/R)24 (L→I)30 (D→N)32 (V→I)33 (L→F)36 (M→I)46 (M→I)48 (G→V)50 (I→V)54 (I→V)63 (L→P)71 (A→V)73 (G→S)82 (V→A/T/F)84 (I→V)90 (L→M)
HIV-1 (wt)LKLDVLMMGIILAGVIL
HIV-2 (wt)VVLDIVIIGIIEVAIIL
HEM-13VVLDIVIIGIIEVAIIL
HSM-22VVLDIVIIGIIEVAIIL
HSM-29VVLDIVIIGIMEIAFIL
HSM-30VVLDIVIIGIIEVAIIL
  • a wt, Wild type.

  • b Consensus wild type amino acid at position indicated followed by its known substitution associated with resistance in HIV-1. The amino acid substitution is indicated in parentheses.