Table 2.

Amino acid substitutions arising in HIV-2-infected patients exposed to NRTI

SampleaAmino acid position in RT coding regionb
41 (M→L)65 (K→R)67 (D→N)69 (T→D)70 (K→R)74 (L→V)75 (V→I)116 (F→Y)151 (Q→M/L)184 (M→V)210 (L→W)215 (T→Y)219 (K→Q/E)333 (G→D/E)
HIV-1 (wt)MKDTKLVFQMLTKG
HIV-2 (wt)MKDNKLIFQMNSEQ
HEM-05KDNKLIFQMNSEQ
HEM-06KDNRLIFQMNSEQ
HEM-14MKDNKLMFQMNSEQ
HEM-16KDNKLIFQMNSEQ
HEM-17KDNKLIFQMNSEQ
HEM-19KDNKLIFMVNSEQ
HEM-20KDNKLIFQMNSEQ
HSM-22KDNKLMFQMNSEQ
HSM-23KDNKLIFQMNSDQ
HSM-29MRDSKLIFMVNSEQ
HSM-30MKDNRLIFQMNSEQ
  • a wt, Wild type.

  • b Consensus wild-type amino acid at position indicated followed by its known substitution associated with resistance in HIV-1. The amino acid substitution is indicated in parentheses.