Table 3.

Amino acid substitutions in HIV-2-infected patients potentially associated with resistance to NNRTI

SampleaAmino acid position in RT coding regionb
98 (A→G)100 (L→I)101 (K→E)103 (K→N/R)106 (V→A/I)108 (V→I)179 (V→D)181 (Y→C/I)188 (Y→C/L)190 (G→A)236 (P→L)
HIV-1 (wt)ALKKVVVYYGP
HIV-2 (wt)ALAKIVIILAP
HEM-05ALPRIVIILAP
HEM-06ALARIVIILAP
HEM-14ALAKIVIILAP
HEM-16ALAKIVIILAP
HEM-17ALAKIVIILAP
HEM-19ALAKIVIILAP
HEM-20ALAKIVIILAP
HSM-22ALAKIVIILAP
HSM-23ALAKIVIILAP
HSM-29ALAKIVIILGP
HSM-30ALAKIVIILAP
  • a wt, Wild type.

  • b Consensus wild-type amino acid at position indicated followed by its known substitution associated with resistance in HIV-1. The amino acid substitution is indicated in parentheses.