Table 1.

Distribution of MICs reported by eight participating facilities each testing two control strains on 10 separate days

Antifungal agent and control strainaIncubation time (h)No. of times the following MICs (μg/ml) were reported (n = 240)b:
≤0.0160.030.060.120.250.51.02.04.08.0163264128
Amphotericin B
C. parapsilosis 247[11201093]
4820[1881238]
C. krusei 24[214197]
48[1020228]
Flucytosine
C. parapsilosis 24[43c 15243]11
484c [1218934]1
C. krusei 2415[3611979]
481[741623]
Fluconazoled
C. parapsilosis 2412[4559115]
48121[4211941]
C. krusei 24[595764]
48[4108980]
Voriconazole
C. parapsilosis 24[9861414]
48[21113833]
C. krusei 244[17761394]
48[01101255]
Ketoconazole
C. parapsilosis 246[710610813]
482[231148217]2
C. krusei 24110[32741230]
48[2514370]1
Itraconazole
C. parapsilosis 2454[3412966]1
485[2814957]1
C. krusei 2419[23681363]
48[2317046]
Caspofungin (MK0991)
C. parapsilosis 24611[2915944]
4815[11143672]92c
C. krusei 243[22981161]
484[2216448]2
Ravuconazole (BMS 207147)
C. parapsilosis 24[9931217]10
483[81149222]1
C. krusei 24610[17729639]
48[831525]
Posaconazole (SCH 56592)
C. parapsilosis 247[3611977]1
4811[1516161]1
C. krusei 24[125110770]
481[3931403]
LY 303366
C. parapsilosis 24432[43111770]
481[31831232]
C. krusei 241[81307523]21
4812[591084414]102
  • a C. parapsilosis ATCC 22019 and C. krusei ATCC 6258.

  • b Proposed QC limits are indicated by brackets.

  • c MICs outside the range of flucytosine or caspofungin that were actually tested.

  • d Data from one laboratory were excluded because MICs of the control drug, amphotericin B, were outside of the proposed limits; another laboratory reported only 48-h readings. A third laboratory experienced growth failures with two lots of broth, especially after 24 h. Consequently, the total number of evaluable fluconazole MICs was less than the 240 expected test results.