Table 1.

Distribution of MICs reported by eight participating facilities each testing two control strains on 10 separate days

Antifungal agent and control strainaIncubation time (h)No. of times the following MICs (μg/ml) were reported (n = 240)b:
≤0.0160.030.060.120.250.51.02.04.08.0163264128
Amphotericin B
C. parapsilosis247[11201093]
4820[1881238]
C. krusei24[214197]
48[1020228]
Flucytosine
C. parapsilosis24[43c15243]11
484c[1218934]1
C. krusei2415[3611979]
481[741623]
Fluconazoled
C. parapsilosis2412[4559115]
48121[4211941]
C. krusei24[595764]
48[4108980]
Voriconazole
C. parapsilosis24[9861414]
48[21113833]
C. krusei244[17761394]
48[01101255]
Ketoconazole
C. parapsilosis246[710610813]
482[231148217]2
C. krusei24110[32741230]
48[2514370]1
Itraconazole
C. parapsilosis2454[3412966]1
485[2814957]1
C. krusei2419[23681363]
48[2317046]
Caspofungin (MK0991)
C. parapsilosis24611[2915944]
4815[11143672]92c
C. krusei243[22981161]
484[2216448]2
Ravuconazole (BMS 207147)
C. parapsilosis24[9931217]10
483[81149222]1
C. krusei24610[17729639]
48[831525]
Posaconazole (SCH 56592)
C. parapsilosis247[3611977]1
4811[1516161]1
C. krusei24[125110770]
481[3931403]
LY 303366
C. parapsilosis24432[43111770]
481[31831232]
C. krusei241[81307523]21
4812[591084414]102
  • a C. parapsilosis ATCC 22019 and C. krusei ATCC 6258.

  • b Proposed QC limits are indicated by brackets.

  • c MICs outside the range of flucytosine or caspofungin that were actually tested.

  • d Data from one laboratory were excluded because MICs of the control drug, amphotericin B, were outside of the proposed limits; another laboratory reported only 48-h readings. A third laboratory experienced growth failures with two lots of broth, especially after 24 h. Consequently, the total number of evaluable fluconazole MICs was less than the 240 expected test results.