Table 5.

IFN-γ levels in PBMC culture supernatants after stimulation with mycobacterial antigens or PHA for Danish outpatient study groups, excluding those not BCG vaccinateda

Antigen or mitogenValue typeLevel (pg/ml) for group (n):
CD (56)UC (64)Control (63)
M. aviumPPDMedian 1,860** 5,326** 9,303
Mean ± SEM3,837 ± 6446,519 ± 7669,829 ± 761
Range1–19,3091–30,0731–21,327
M. bovisPPDMedian 2,243** 4,176** 10,734
Mean ± SEM4,628 ± 7176,053 ± 77111,685 ± 1,085
Range1–18,2451–29,5421–46,100
PHAMedian10,492** 9,468** 15,631
Mean ± SEM10,144 ± 7409,635 ± 65414,598 ± 801
Range482–19,4251–19,6621–25,932
  • a Kruskal-Wallis nonparametric ANOVA with Dunn's multiple comparisons test. For IFN-γ release after M. avium PPD stimulation, CD < UC (P < 0.05). For IFN-γ release after M. bovis PPD or PHA stimulation, CD and UC groups were not significantly different. Asterisks denote comparison of CD and UC groups to controls: *, P < 0.01; **, P < 0.001.