Table 2.

Overall absolute and relative (within 0 and 1 dilutions, respectively) agreements within the four observers and the three experiments for all tested Aspergillus isolates

AgreementGroupaDrugGrowth levelbOverall absolute (relative) % agreement for the indicated method after the following h of incubation:
2448
NCCLSXTTNCCLSXTT
Intraexperimental1ITC082.9 (99.1)90.3 (97.7)89.7 (99.4)92.5 (99.5)
183.2 (98.6)77.6 (99.1)76.1 (99.5)82.0 (98.8)
269.0 (88.8)66.9 (87.6)69.8 (95.3)72.0 (94.9)
362.4 (80.2)59.1 (73.6)65.5 (78.2)65.0 (86.7)
460.8 (71.7)63.2 (71.8)64.1 (77.0)63.5 (70.3)
AMB091.0 (99.8)96.1 (99.9)90.6 (100)95.8 (100)
Interexperimental2ITC078.3 (97.6)75.3 (95.6)83.7 (99.4)85.6 (99.3)
169.6 (95.5)74.5 (96.6)78.3 (98.9)77.0 (98.6)
265.8 (85.7)64.6 (85.3)71.5 (94.3)68.8 (93.3)
362.8 (82.2)57.7 (75.9)67.7 (82.5)69.1 (87.8)
461.9 (73.8)58.5 (68.4)66.0 (79.3)66.8 (77.2)
AMB081.7 (99.0)87.9 (99.7)78.1 (99.7)83.1 (99.7)
3ITC054.7 (76.2)64.4 (90.9)75.4 (91.6)87.3 (99.4)
171.2 (99.7)74.8 (95.7)84.7 (97.6)81.0 (97.2)
265.6 (96.2)63.4 (93.1)72.3 (99.7)67.0 (89.6)
358.8 (71.4)56.0 (80.2)62.9 (89.6)49.3 (88.9)
461.7 (64.3)61.7 (67.0)59.5 (64.8)56.1 (78.2)
AMB078.9 (99.7)88.2 (100)92.4 (100)89.6 (100)
  • a Groups 1 and 2, NCCLSvisand XTTvis, 95% CI limits of absolute agreement ranged from ±3.6 to ±5.6%; group 3, NCCLSsp and XTTsp, 95% CI limits of absolute agreement ranged from ±2.6 to ±11.3%.

  • b Growth levels: 0, no visible growth (≤5% that of growth control); 1 slight growth (6 to 25% that of growth control); 2, prominent reduction of growth (26 to 50% that of growth control); 3, slight reduction of growth (51 to 75% that of growth control); 4, no reduction of growth (76 to 100% of growth control).