Table 1.

Susceptibilities of five strains of fiveAspergillus spp. to AMB and ITC based on MIC-0 and MIC-2, respectively, after 24 and 48 h of incubation

DrugTime (h)SpeciesGeometric mean (range) MIC, in mg/liter, determined by the following method:
NCCLSvisNCCLSspXTTvisXTTsp
AMB24 A. fumigatus 0.68 (0.125–4)0.63 (0.5–2)0.63 (0.25–2)0.63 (0.5–2)
A. flavus 1.19 (0.5–4)1.20 (0.5–2)1.11 (0.5–2)1.15 (0.5–2)
A. nidulans 0.74 (0.25–4)0.72 (0.25–2)0.68 (0.25–2)0.66 (0.25–1)
A. terreus 1.11 (0.5–4)0.95 (0.5–4)1.07 (0.5–2)1.10 (0.5–2)
A. ustus 1.11 (0.5–2)0.88 (0.5–2)0.92 (0.5–4)1.12 (0.5–2)
48 A. fumigatus 1.50 (1–4)1.26 (1–4)1.14 (0.5–4)1.15 (0.5–4)
A. flavus 1.64 (1–4)1.38 (1–2)1.57 (1–4)1.45 (1–2)
A. nidulans 1.10 (0.25–4)0.87 (0.25–4)0.97 (0.25–4)0.95 (0.25–4)
A. terreus 2.89 (2–4)2.09 (2–4)2.64 (2–4)2.52 (2–4)
A. ustus 1.91 (1–4)1.36 (1–2)1.53 (1–4)1.47 (1–2)
ITC24 A. fumigatus 2.39 (0.015–>32)1.15 (0.125–>32)1.36 (0.125–>32)1.38 (0.125–>32)
A. flavus 0.14 (0.063–0.25)0.10 (0.063–0.125)0.14 (0.0125–0.5)0.14 (0.063–0.25)
A. nidulans 0.13 (0.031–0.5)0.13 (0.063–0.25)0.13 (0.062–0.5)0.10 (0.062–0.5)
A. terreus 0.09 (0.031–0.25)0.09 (0.063–0.125)0.12 (0.062–0.5)0.11 (0.063–0.125)
A. ustus 0.40 (0.062–1)0.35 (0.063–1)0.54 (0.062–1)0.46 (0.063–1)
48 A. fumigatus 2.89 (0.125–>32)2.41 (0.125–>32)2.96 (0.125–>32)2.10 (0.063–>32)
A. flavus 0.19 (0.125–0.5)0.12 (0.063–0.25)0.26 (0.125–1)0.24 (0.125–0.5)
A. nidulans 0.16 (0.062–0.25)0.20 (0.063–2)0.17 (0.031–0.5)0.15 (0.031–0.5)
A. terreus 0.15 (0.062–0.5)0.14 (0.063–0.25)0.29 (0.062–0.5)0.23 (0.125–0.5)
A. ustus 1.48 (0.125–>32)0.89 (0.5–1)3.21 (0.125–>32)2.72 (0.25–>32)