Table 2.

Percent agreement between YeastOne panel and NCCLS reference method for ranking isolates of common Candidaspp. within the established breakpointsa

Antifungal agentCategory and breakpoint (μg/ml)b% Agreement by species (no. of isolates at each breakpoint)
C. albicansC. glabrataC. kruseiC. lusitaniaeC. parapsilosisC. tropicalis
FluconazoleS (≤8)89 (442)96 (49)NAc96 (76)98 (87)95 (89)
S-DD (16–32)75 (12)94 (32)NAND (0)ND (7)ND (2)
R (≥64)93 (14)100 (14)NAND (1)ND (1)ND (3)
ItraconazoleS (≤0.12)91 (346)ND (5)ND (6)93 (30)100 (38)100 (39)
S-DD (0.2–0.5)24 (104)97 (40)100 (49)98 (43)100 (54)89 (48)
R (≥1.0)50 (18)90 (48)100 (12)ND (4)ND (3)ND (7)
FlucytosineS (≤4)88 (446)98 (93) 91 (23)98 (64)99 (95)95 (88)
I (8–16)ND (2)ND (0)100 (44)ND (1)ND (0)ND (2)
R (≥32)75 (20)ND (2)ND (0)100 (12)ND (0)ND (4)
  • a MICs were read at 24 h for both methods. ND, not determined.

  • b NCCLS breakpoints: S, susceptible; S-DD, susceptible-dose dependent; I, intermediate; R, resistant.

  • c NA, not applicable: the breakpoints do not apply to C. krusei and fluconazole (intrinsically resistant species).