Table 1.

Percent agreement between colorimetric and NCCLS reference broth microdilution MIC pairsa

Fungus (no. of isolates tested)Antifungal agent% Agreement (range) between MIC pairs at incubation time (h)
24 vs 2448 vs 4824 vs 48
C. albicans (465)Amphotericin B 979776
Fluconazole 876071
Flucytosine 875689
Itraconazole 895476
Ketoconazole 905669
Other commonCandida spp. (417)bAmphotericin B85–97 92–99 40–75
Fluconazole95–98 73–99 91–99
Flucytosine92–99 73–10089–97
Itraconazole93–10066–97 86–97
Ketoconazole93–10066–97 85–97
Emerging Candida spp. (64)cAmphotericin B 909063
Fluconazole 989497
Flucytosine 959977
Itraconazole 929190
Ketoconazole 959485
C. neoformans (107)dAmphotericin BND76ND
Miscellaneous yeasts and yeast-like organisms (68)eAmphotericin B 919967
Flucytosine 999994
Itraconazole 979590
Ketoconazole 949790
  • a Sensititre YeastOne Colorimetric Antifungal Panel MICs versus NCCLS broth microdilution M27-A MICs. An incubation time of 48 to 96 h was used for C. neoformans and certain emerging yeast pathogens. ND, not determined.

  • b Species included 77 to 95 isolates each ofC. glabrata, C. krusei, C. lusitaniae,C. parapsilosis, and C. tropicalis.

  • c Species included 5 to 26 isolates each ofC. ciferrii, C. famata, C. guilliermondii, C. kefyr, C. lambica,C. lypolytica, C. rugosa, and C. zeylanoides.

  • d The eight non-C. neoformans Cryptococcus isolates tested are not listed.

  • e Species included 2 to 23 isolates each ofB. capitatus, H. anomala, R. rubra,R. minuta, S. cerevisiae, S. salmonicolor, and T. beigelii.