Table 2.

Histopathologic lesion and cyst scores and Western immunoblot and PCR results in rats during cyclophosphamide inductiona

Animal no.Weeks of inductionPulmonary histopathologyWestern immunoblotting (no. positive/no. tested)PCR (no. positive/no. tested)
Overall inflammationPneumocystosis lesionsbGMS cyst scoreb (no. positive/no. tested)PreinductionTerminal
28–3010.660.330.00 (0/3)2/32/32/3
31–3322.001.330.66 (2/3)1/21/22/3
34Died NDc NDNDNDNDND
35–3631.000.501.00 (2/2)2/22/22/2
37–3941.330.331.66 (3/3)3/33/33/3
1–342.332.002.33 (3/3)3/33/33/3
4–651.331.661.33 (2/3)3/33/32/3
7–962.332.331.33 (3/3)3/33/32/3
10–1281.330.330.33 (1/3)3/32/31/3
  Total or avg1.541.101.08 (16/23)20/2319/2317/23
  • a Histopathologic scoring is described in note a to Table 1.

  • b Means of groups of 3 rats.

  • c ND, not done.