Table 1.

Sensitivity of the C6 ELISAa

Serum panel (institution)Disease phaseNo. of specimensNo. positiveNo. negativesSensitivity (%)
1 (CDC)Convalescent4034685
2 (Tufts)Acute39291074
Convalescent3935490
Early disseminated (neuroborreliosis)2019195
Late (arthritis)49490100
Late (neuroborreliosis)10100100
3 (NIH)Posttreatment Lyme disease syndrome138562
  • a The cutoff OD value (0.500) was defined as the mean plus 3 SDs for 97 serum samples obtained from hospitalized patients in an area where Lyme disease is not endemic. C6ELISA was performed as described in Materials and Methods.