Table 3.

Geometric mean MICs and ranges of MICs of voriconazole after 24, 48, and 72 h

SpeciesNo. of isolatesMediumGMa (range) MIC (μg/ml)
24 h48 h72 h
Aspergillus
A. flavus27RPMI0.16 (0.03–0.5)0.25 (0.03–0.5)0.36 (0.06–1)
RPMI-20.19 (0.06–0.5)0.29 (0.125–1)0.35 (0.125–1)
AM30.22 (0.06–0.5)0.35 (0.125–0.5)0.42 (0.125–0.5)
A. fumigatus26
 General isolates24RPMI0.17 (0.125–0.5)0.24 (0.125–0.5)0.27 (0.125–0.5)
RPMI-20.3 (0.125–0.5)0.3 (0.125–0.5)0.32 (0.125–1)
AM30.18 (0.06–0.5)0.26 (0.125–0.5)0.34 (0.25–0.5)
 Itraconazole-resistant isolates2RPMI0.125 (0.125)0.18 (0.125–0.25)0.18 (0.125–0.25)
RPMI-20.18 (0.125–0.25)0.25 (0.125–0.5)0.35 (0.25–0.5)
AM30.09 (0.06–0.125)0.25 (0.125–0.5)0.25 (0.125–0.5)
A. niger17RPMI0.11 (0.03–0.5)0.24 (0.06–0.5)0.32 (0.06–1)
RPMI-20.15 (0.06–0.5)0.35 (0.06–1)0.42 (0.06–1)
AM30.09 (0.03–0.5)0.18 (0.125–0.5)0.28 (0.125–1)
A. terreus9RPMI0.16 (0.06–1)0.25 (0.125–2)0.37 (0.125–2)
RPMI-20.17 (0.06–1)0.32 (0.25–1)0.4 (0.25–2)
AM30.17 (0.125–0.25)0.29 (0.125–0.5)0.29 (0.125–0.5)
A. nidulansb3RPMI0.5 (0.5)0.5 (0.5)
RPMI-20.5 (0.5)0.5 (0.5)
AM30.25 (0.25)0.25 (0.25)
Fusarium
F. solani18RPMI1.92 (0.25–4)3.43 (1–8)4.16 (1–8)
RPMI-21.78 (0.25–4)4 (1–16)5.04 (1–16)
AM30.76 (0.25–2)1.78 (1–8)3.05 (1–8)
F. oxysporum4RPMI0.5 (0.25–1)1.41 (1–2)2 (1–4)
RPMI-20.5 (0.5)1.68 (1–4)1.68 (1–4)
AM30.84 (0.5–1)1 (0.5–2)1.41 (1–4)
  • a GM, geometric mean.

  • b No growth at 24 h.