Table 1.

Geometric mean MICs and ranges of MICs of amphotericin B after 24, 48, and 72 h

SpeciesNo. of isolatesMediumGMa (range) MIC (μg/ml)
24 h48 h72 h
Aspergillus
A. flavus27RPMI0.9 (0.5–2)1.17 (1–4)1.63 (1–4)
RPMI-20.81 (0.25–2)1.14 (1–4)1.43 (1–4)
AM30.57 (0.5–1)1.03 (0.5–4)1.33 (0.5–4)
A. fumigatus26
 General isolates24RPMI0.87 (0.5–1)1.33 (1–2)2.18 (1–4)
RPMI-20.73 (0.5–1)1.3 (1–4)1.94 (1–4)
AM30.36 (0.25–1)0.65 (0.25–1)1.09 (0.5–2)
 Itraconazole-resistant isolates2RPMI1 (1)1.41 (1–2)1.41 (1–2)
RPMI-21 (1)1.41 (1–2)2.83 (2–4)
AM30.25 (0.25)0.71 (0.5–1)1 (1)
A. niger17RPMI0.33 (0.125–1)0.54 (0.25–1)0.75 (0.25–2)
RPMI-20.26 (0.06–0.5)0.32 (0.125–1)0.54 (0.25–1)
AM30.09 (0.03–0.25)0.29 (0.125–0.5)0.44 (0.125–1)
A. terreus9RPMI0.63 (0.25–1)2.33 (0.5–>4)4.32 (1–>4)
RPMI-20.63 (0.25–1)1.85 (0.5–>4)3.17 (0.5–>4)
AM30.68 (0.125–1)2.94 (0.5–>4)4.67 (0.5–>4)
A. nidulansb3RPMI1 (1)2 (2)
RPMI-22 (2)2 (2)
AM30.5 (0.5)1 (1)
Fusarium
F. solani18RPMI1.85 (1–4)3.3 (1–>4)4.39 (2–>4)
RPMI-21.53 (0.5–4)2.83 (1–>4)3.17 (1–>4)
AM32 (0.5–>4)2.83 (1–>4)3.56 (1–>4)
F. oxysporum4RPMI2.38 (2–4)3.36 (2–4)4 (4)
RPMI-22 (2)2.83 (2–4)4 (4)
AM32 (1–2)5.66 (4–>4)6.73 (4–>4)
  • a GM, Geometric mean.

  • b No growth at 24 h.