Table 5.

Evaluation of MICs in AM3 compared to those in RPMI forAspergillus and Fusariuma

Drug and speciesNo. (%) of isolates for which MIC in AM3 is as follows compared to MIC in RPMIb:
≥−2−10+1≥+2
Amphotericin B
Aspergillus24 (30.4)35 (44.3)16 (20.3)4 (5.1)
Fusarium7 (31.8)8 (36.4)7 (31.8)
Itraconazole
Aspergillus13 (16.4)20 (25.3)35 (44.3)10 (12.7)1 (1.3)
Fusarium21 (95.5)1 (4.6)
Voriconazole
Aspergillus1 (1.3)13 (16.6)44 (55.7)20 (25.3)1 (1.3)
Fusarium8 (36.4)7 (31.8)5 (22.7)1 (4.6)1 (4.6)
  • a The MICs for 79 Aspergillusisolates and 22 Fusarium isolates which were readable after 24 h were analyzed.

  • b ≥−2, MIC in AM3 is twofold or more than twofold lower; −1, MIC in AM3 is onefold lower; 0, MIC in AM3 is identical to MIC in RPMI; +1, MIC in AM3 is onefold higher; ≥+2, MIC in AM3 is twofold or more than twofold higher.