Table 4.

Evaluation of MICs in RPMI-2 compared to those in RPMI for Aspergillusand Fusariuma

Drug and speciesNo. (%) of isolates for which MIC in RPMI-2 is as follows compared to MIC in RPMIb:
≥−2−10+1≥+2
Amphotericin B
Aspergillus18 (22.8)60 (76)1 (1.3)
Fusarium1 (4.6)6 (27.3)13 (59.1)2 (9.1)
Itraconazole
Aspergillus1 (1.3)7 (8.9)37 (46.8)33 (41.8)1 (1.3)
Fusarium19 (86.4)1 (4.6)2 (9.1)
Voriconazole
Aspergillus4 (5.1)45 (57)26 (33)4 (5.1)
Fusarium5 (22.7)14 (63.6)3 (13.6)
  • a The MICs for 79 Aspergillusisolates and 22 Fusarium isolates which were readable after 24 h were analyzed.

  • b ≥−2, MIC in RPMI-2 is twofold or more than twofold lower; −1, MIC in RPMI-2 is onefold lower; 0, MIC in RPMI-2 is identical to MIC in RPMI; +1, MIC in RPMI-2 is onefold higher; ≥+2, MIC in RPMI-2 is twofold or more than twofold higher.