TABLE 5

GM MIC or MEC and MIC or MEC ranges of amphotericin B, fluconazole, itraconazole, voriconazole, posaconazole, isavuconazole, anidulafungin, and micafungin for strains of M. capitatus and S. clavata

SpeciesMICa (μg/ml)
AMBFLUITCVRCPOSISAVAFGMFG
MIC (μg/ml)MIC (μg/ml)MIC (μg/ml)MIC (μg/ml)MIC (μg/ml)MIC (μg/ml)MEC (μg/ml)MEC (μg/ml)
RangeGMRangeGMRangeGMRangeGMRangeGMRangeGMRangeGMRangeGM
M. capitatus (n = 21)0.063–10.328–3212.280.125–0.50.280.125–0.50.180.125–0.50.240.063–10.342–42.42–>86.6
S. clavata (n = 8)0.125–0.50.2216–32190.25–0.50.270.063–0.50.250.250.250.125–10.54224–86.7
  • a MICs were determined according to CLSI methods after 48 h of incubation at 35°C. AMB, amphotericin B; FLU, fluconazole; ITC, itraconazole; VRC, voriconazole; POS, posaconazole; ISAV, isavuconazole; AFG, anidulafungin; MFG, micafungin; GM, geometric mean; MEC, minimum effective concentration.