Table 2.

Geometric mean MICs and ranges of MICs of itraconazole after 24, 48, and 72 h

SpeciesNo. of isolatesMediumGMa (range) MIC (μg/ml)
24 h48 h72 h
Aspergillus
A. flavus27RPMI0.17 (0.03–0.25)0.19 (0.03–0.25)0.25 (0.06–0.5)
RPMI-20.26 (0.06–0.5)0.29 (0.06–0.5)0.32 (0.125–0.5)
AM30.17 (0.03–0.25)0.22 (0.03–0.5)0.25 (0.125–0.5)
A. fumigatus26
 General isolates24RPMI0.28 (0.06–0.5)0.42 (0.25–1)0.47 (0.25–1)
RPMI-20.3 (0.06–0.5)0.4 (0.125–2)0.49 (0.25–1)
AM30.13 (0.03–0.25)0.31 (0.125–0.5)0.31 (0.25–0.5)
 Itraconazole-resistant isolates2RPMI2.83 (0.25–>16)>16 (>16)>16 (>16)
RPMI-21.41 (0.5–4)>16 (>16)>16 (>16)
AM30.35 (0.25–0.5)2 (2)2 (2)
A. niger17RPMI0.24 (0.03–1)0.42 (0.06–2)0.59 (0.06–2)
RPMI-20.29 (0.06–1)0.44 (0.06–1)0.52 (0.06–1)
AM30.16 (0.03–0.5)0.25 (0.03–1)0.38 (0.06–1)
A. terreus9RPMI0.1 (0.03–0.25)0.17 (0.125–0.25)0.17 (0.125–0.25)
RPMI-20.15 (0.03–0.5)0.2 (0.03–0.5)0.25 (0.06–0.5)
AM30.15 (0.03–0.25)0.16 (0.03–0.25)0.18 (0.03–0.25)
A. nidulansb3RPMI0.5 (0.5)0.5 (0.5)
RPMI-20.5 (0.5)0.5 (0.5)
AM30.25 (0.25)0.25 (0.25)
Fusarium
F. solani18RPMI>16 (>16)>16 (>16)>16 (>16)
RPMI-2>16 (>16)>16 (>16)>16 (>16)
AM3>16 (>16)>16 (>16)>16 (>16)
F. oxysporum4RPMI0.11 (0.03–0.25)0.5 (0.5)22.6 (8–>16)
RPMI-20.42 (0.25–0.5)0.5 (0.5)19 (4–>16)
AM30.15 (0.03–0.25)0.35 (0.25–0.5)1.41 (1–2)
  • a GM, geometric mean.

  • b No growth at 24 h.