TABLE 2.

Summary of reviewed studies dealing with BACTEC MGIT 960 systema

DrugAuthors (reference)YrCC (μg/ml)No. of:Sens.Spec.PPVNPVDOR
Tested strainsTPFNFPTN
RMPArdito et al. (5)20011.078780001.00NA1.00NA5.06
Bemer et al. (6)20021.01109200181.001.001.001.008.83
Tortoli et al. (38)20021.01321241070.991.001.000.837.13
Johansen et al. (16)20041.022219900231.001.001.001.009.84
Scarparo et al. (33)20041.01007001291.000.970.991.007.93
EMBArdito et al. (5)20015.0786430110.961.001.000.796.05
7.578760021.001.001.001.006.64
Bemer et al. (6)20025.01109430130.971.001.000.816.59
Tortoli et al. (38)20025.01331251160.990.860.990.866.62
Johansen et al. (16)20045.022220322150.990.880.990.886.63
Scarparo et al. (33)20045.01007803191.000.860.961.006.77
7.51008610130.991.001.000.937.35
PZAPfyffer et al. (29)2002100584521100.960.910.980.835.42b
100584410130.981.001.000.936.69c
Kontos et al. (18)20031001501440061.001.001.001.008.23
Johansen et al. (16)2004100574600111.001.001.001.007.67
Scarparo et al. (33)20041001006634270.960.870.940.905.00
  • a Data are reported by individual drug. DORs are expressed as logarithms. TP, true positive; FN, false negative; FP, false positive; TN, true negative; Sens., sensitivity; Spec., specificity; PPV, positive predictive value; NPV, negative predictive value; NA, not available.

  • b DST involved inoculation with a primary MGIT tube.

  • c DST involved inoculation with a strain suspension obtained from a solid culture.