TABLE 3.

Frequency distribution of genetic groups, Beijing/W lineage, age, gender, race/ethnicity, HIV serostatus, and plcD genotype between the two sites of disease assessed by bivariate χ2 test or Fisher's exact test

VariableNo. (%) positive for:P value
TTBa (n = 598)ETTBb (n = 78)
Genetic group0.1685
    2394 (65.9)44 (56.4)
    152 (8.7)11 (14.1)
    3152 (25.4)23 (29.5)
Beijing/W lineagec0.0617
    No567 (95.1)70 (89.7)
    Yes29 (4.9)8 (10.3)
Age (yr)0.3217
    <65294 (49.2)43 (55.1)
    ≤65304 (50.8)35 (44.9)
Gender0.0013
    Male395 (66.1)37 (47.4)
    Female203 (33.9)41 (52.6)
Race/ethnicity0.0013
    Non-Hispanic White350 (58.5)29 (37.2)
    Non-Hispanic Black193 (32.3)40 (51.3)
    Other55 (9.2)9 (11.5)
HIV serostatus0.0004
    Negative276 (46.2)36 (16.2)
    Positive16 (2.7)9 (11.5)
    Unknown306 (51.2)33 (42.3)
plcD genotype0.0293
    plcD wild type401 (67.1)44 (56.4)
    plcD mutation29 (4.8)9 (11.5)
    plcD and adjacent gene mutation168 (28.1)25 (32.1)
  • a TTB, thoracic TB.

  • b ETTB, extrathoracic TB.

  • c Spoligotyping results were not available for two isolates, and, therefore, only 674 of the 676 isolates/patients were included in this analysis.