TABLE 1.

Activities of micafungin and caspofungin against 315 invasive clinical isolates of Candida spp. that are resistant to fluconazolea

Organism (no. of isolates)AntifungalMIC (μg/ml)Cumulative % of isolates susceptible at an MIC of (μg/ml):
Range50%90%0.030.060.120.250.51.02.0
C. albicans (41)Micafungin0.007-0.250.0150.03959797100
Caspofungin0.007-2.00.030.06619595979797100
C. glabrata (110)Micafungin0.007-0.060.0150.01597100
Caspofungin0.015-0.50.030.06599096100
C. krusei (146)Micafungin0.007-.250.060.06269399100
Caspofungin0.015-0.50.120.251418197100
Candida spp. (18)Micafungin0.007-1.00.251.03338446177100
Caspofungin0.015-0.50.060.522505077100
All Candida spp. (315)Micafungin0.007-1.00.030.066093969798100
Caspofungin0.007-2.00.060.25306686979999100
  • a Resistance to fluconazole was indicated by a C. krusei or fluconazole MIC of >32 μg/ml.