TABLE 1.

Best-fit values of EC50 and bottom of the sigmoid curve obtained with the Emax model for early XTT (6-, 8-, and 12-h) and spectrophotometric (24-h) readings

DrugaIsolateEC50 (95% CI)c (μg/ml)Bottom values (95% CI) (relative OD450)
SPECb24 hXTT 6 hXTT 8 hXTT 12 hSPEC 24 hXTT 6 hXTT 8 hXTT 12 h
AMBR. oryzae0.31 (0.27-0.36)0.13 (0.11-0.14)0.14 (0.08-0.22)0.16 (0.15-0.17)−0.01 (−0.04-0.00)0.03 (0.00-0.06)0.00 (−0.06-0.07)0.00 (0.00-0.01)
C. bertholletiae1 (0.87-1.14)0.57 (0.49-0.66)0.62 (0.52-0.74)0.69 (0.67-0.72)−0.02 (−0.04-0.01)0.01 (−0.05-0.07)0.02 (−0.04-0.08)0.01 (0.00-0.02)
M. circinelloides0.22 (0.01-1.8)0.15 (0.09-0.24)0.16 (0.12-0.22)0.18 (0.16-0.19)0.00 (−0.04-0.03)0.03 (0.01-0.05)0.00 (−0.02-0.03)0.00 (−0.01-0.01)
A. corymbifera0.27 (0.24-0.29)0.15 (0.10-0.22)0.12 (0.11-0.13)0.16 (0.14-0.18)−0.02 (−0.06-0.07)0.04 (−0.04-0.13)0.01 (−0.01-0.04)0.00 (−0.02-0.04)
PSCR. oryzae0.18 (0.16-0.22)0.18 (0.16-0.21)0.15 (0.12-0.17)0.16 (0.15-0.17)0.01 (−0.03-0.05)0.38 (0.36-0.39)0.14 (0.09-0.18)0.13 (0.12-0.14)
C. bertholletiae0.03 (0.01-0.2)0.06 (0.03-0.16)0.07 (0.05-0.09)0.19 (0.17-0.22)0.01 (−0.04-0.07)0.21 (0.11-0.30)0.10 (0.06-0.13)0.04 (0.01-0.08)
M. circinelloides0.52 (0.43-0.62)0.29 (0.22-0.38)0.37 (0.31-0.44)0.51 (0.44-0.59)0.00 (−0.09-0.08)0.16 (0.09-0.23)0.08 (0.03-0.13)0.04 (−0.01-0.1)
A. corymbifera0.18 (0.1-0.3)0.28 (0.25-0.32)0.22 (0.21-0.24)0.19 (0.16-0.22)−0.04 (−0.16-0.08)0.20 (0.17-0.23)0.08 (0.06-0.11)0.01 (−0.03-0.05)
VRCR. oryzae2.56 (2.21-2.97)1.54 (0.58-4.06)0.8 (0.61-1.05)1.33 (1.20-1.48)0.00 (−0.03-0.05)0.26 (0.17-0.35)0.11 (0.07-0.14)0.09 (0.07-0.11)
C. bertholletiae1.58 (0.37-6.73)1.23 (0.59-2.53)1.31 (0.95-1.81)4.66 (4.15-5.23)−0.03 (−0.09-0.8)0.08 (0.02-0.14)0.05 (0.02-0.08)0.04 (0.00-0.07)
M. circinelloides21.94 (18.8-25.59)8.31 (6.97-9.92)12.68 (10.86-14.80)18.16 (15.74-20.95)0.00 (−0.05-0.06)0.16 (0.11-0.2)0.06 (0.01-0.1)0.03 (−0.01-0.07)
A. corymbifera4.63 (2.98-7.18)8.55 (6.70-10.92)4.61 (3.78-5.63)4.27 (3.82-4.77)−0.03 (−0.12-0.05)0.15 (0.1-0.2)0.06 (0.02-0.1)0.00 (−0.01-0.02)
  • a AMB, amphotericin B; PSC, posaconazole; VRC, voriconazole.

  • b SPEC, spectrophotometric.

  • c CI, confidence interval.