TABLE 3.

MICs of zygomycete isolates determined by the early XTT (6-, 8-, and 12-h) and CLSI methodsa

DrugbSpecies (n)Median (range) MIC (μg/ml)
VIS 24 hSPEC 24 hXTT 6 hXTT 8 hXTT 12 h
AMB, MIC-0R. oryzae (5)1 (1-2)1 (0.5-2)0.5 (0.5-1)0.5 (0.5-1)0.5 (0.5-1)
Cunninghamella spp. (3)4 (4-32)4 (4-32)4 (2-8)4 (4-16)4 (2-16)
Mucor spp. (3)1 (1-1)1 (0.5-1)1 (0.5-1)0.5 (0.5-1)0.5 (0.5-1)
A. corymbifera (3)1 (1-1)1 (1-1)0.5 (0.5-1)0.5 (0.5-1)0.5 (0.5-1)
All isolates (14)1 (1-32)1 (0.5-32)1 (0.5-8)0.5 (0.5-16)1 (0.5-16)
PSC, MIC-0R. oryzae (5)1 (0.5-2)1 (0.5-2)0.5 (0.25-16)0.5 (0.25-1)1 (0.5-1)
Cunninghamella spp. (3)1 (1-64)1 (0.5-2)0.5 (0.5-64)1 (0.5-16)1 (0.5-1)
Mucor spp. (3)2 (1-4)2 (0.5-2)1 (0.5-2)1 (1-2)2 (1-2)
A. corymbifera (3)1 (0.5-1)1 (0.5-1)1 (0.25-1)0.5 (0.5-1)0.5 (0.5-1)
All isolates (14)1 (0.5-64)1 (0.5-2)0.5 (0.25-64)1 (0.25-16)1 (0.5-2)
PSC, MIC-2R. oryzae (5)0.5 (0.5-1)0.5 (0.5-1)0.5 (0.13-1)0.25 (0.25-0.5)0.5 (0.25-1)
Cunninghamella spp. (3)0.5 (0.5-1)0.13 (0.06-0.5)0.5 (0.5-64)0.25 (0.25-1)0.5 (0.5-1)
Mucor spp. (3)2 (0.5-2)1 (0.25-2)1 (0.25-2)1 (0.03-1)1 (0.5-2)
A. corymbifera (3)0.5 (0.5-0.5)0.5 (0.25-0.5)0.5 (0.25-1)0.25 (0.25-0.5)0.5 (0.25-0.5)
All isolates (14)0.5 (0.5-2)0.5 (0.06-2)0.5 (0.13-64)0.5 (0.03-1)0.5 (0.25-2)
VRC, MIC-0R. oryzae (5)16 (8-32)16 (8-32)8 (4-256)8 (4-16)8 (8-16)
Cunninghamella spp. (3)32 (32-1024)32 (16-128)32 (16-1024)32 (16-128)16 (16-128)
Mucor spp. (3)256 (32-512)128 (16-256)64 (16-256)64 (16-128)128 (32-256)
A. corymbifera (3)64 (32-128)32 (16-128)64 (4-128)16 (8-64)16 (8-64)
All isolates (14)32 (8-1024)24 (8-256)16 (4-1024)16 (4-128)16 (8-256)
VRC, MIC-2R. oryzae (5)8 (8-16)8 (8-8)4 (4-16)4 (2-8)4 (4-8)
Cunninghamella spp. (3)16 (16-64)16 (4-64)8 (8-512)8 (8-64)16 (8-32)
Mucor spp. (3)128 (16-128)64 (16-128)32 (8-128)32 (8-64)64 (16-128)
A. corymbifera (3)16 (8-32)8 (4-16)8 (4-32)4 (4-16)8 (4-16)
All isolates (14)16 (8-128)8 (4-128)8 (4-512)8 (2-64)8 (4-128)
  • a Visual (VIS) and spectrophotometric (SPEC) readings at 24 h.

  • b AMB, amphotericin B; PSC, posaconazole; VRC, voriconazole.