TABLE 2.

Sites of putative amino acid sequence differences in the HA and NA proteins of the H1N2 viruses described in this study

Amino acid residueaA/Swine/Ontario/ 52156/03bA/Swine/Ontario/ 48235/04cA/Swine/Ontario/ 55383/04cPIRsd
HA 19PTT
HA 42ATT
HA 111YHHD
HA 145VIIF
HA 158SRRG
HA 414NSS
HA 467SGG
HA 541VII
NA 24TMM
NA 40YYQA′
NA 147DDNC′
NA 172KRR
NA 216SGG
NA 265TII
NA 332SFFF′
NA 339DNDF′
NA 399DEE
NA 401DGGK′
NA 402NNSK′
NA 412VIV
NA 431NKK
NA 432QEE
NA 435EKK
NA 437LWW
  • a Numbering is based on defining the first amino acid of the open reading frame of each gene as amino acid 1.

  • b A/Swine/Ontario/52156/03 is a wholly human H1N2 virus.

  • c A/Swine/Ontario/48235/04 and A/Swine/Ontario/55383/04 are reassortant viruses with HA, NA, and PBI genes of human influenza virus lineages and the remaining genes of classical swine virus lineage.

  • d PIRs were previously defined by Taubenberger and coworkers (10, 11).