TABLE 3.

Comparison of the in vitro susceptibility of Candida isolates collected before (1992-2000) and after (2001-2004) the clinical introduction of caspofungina,b

YrNo. of isolates testedCumulative % at MIC (μg/ml)
0.0070.0150.030.060.120.250.51248>8
1992-2000c3,322d2338688488939899999999100
20011,783163568838895999999100
20022,2392842688185919899999999100
20032,287728607881899899999999100
20041,888114547882899899999999100
2001-20048,19713306280849198999999100
  • a All isolates tested in RPMI 1640 broth with 24-h incubation and a prominent reduction endpoint criteria (MIC-2).

  • b All isolates were from blood or from normally sterile site infections.

  • c Data were compiled from reference 23.

  • d Eight of 11 isolates for which MICs were ≥2 μg/ml are glucan synthesis mutants.