TABLE 2.

Fluconazole and voriconazole susceptibilities of 205 Candida sp. isolates, CAs, and errors between VK2 and CLSI/Etest methods at 24 and 48 h

Species (no. of isolates), azole, and method% of isolates (24 h/48 h)a that were:% CA with VK2 (24 h/48 h)aNo. of VK2 errors (24 h/48 h)a
SusceptibleSDDResistantVMEMEmE
C. albicans (84)
    Fluconazole
        VK298.801.2
        CLSI98.801.2100000
        Etest98.801.2100000
    Voriconazole
        VK210000
        CLSI100/98.80/1.20100/98.8001
        Etest100/98.80/1.20100/98.8001
C. parapsilosis (22), C. tropicalis (17), other spp. (5)b
    Fluconazole + voriconazole
        VK210000
        CLSI10000100000
        Etest10000100000
C. glabrata (56)
    Fluconazole
        VK27516.18.9
        CLSI80.314.35.478.60111
        Etest71.5/12.516/23.212.5/64.377.3/23.21/231/012/20
    Voriconazole
        VK287.55.47.1
        CLSI89.3/85.77.2/10.73.5/3.689.3/87.5004/5
        Etest89.3/48.27.2/10.73.5/41.189.2/51.80/201/05/7
C. inconspicua (5), C. norvegensis (2)
    Fluconazole
        VK242.8542.8514.3
        CLSI28.671.4071.4001/2
        Etest28.6/071.4/28.60/71.475/14.30/101/5
    Voriconazole
        VK210000
        CLSI10000100000
        Etest100/85.70/14.30100/85.7000/1
C. krusei (14)
    Fluconazole
        VK2c00100
        CLSI35.7/7.157.1/64.37.1/28.67.1/28.605/18/9
        Etest07.192.992.9001
    Voriconazole
        VK210000
        CLSI10000100000
        Etest100/85.70/14.30100/85.7002
  • a Interpretative results obtained at 48 h if different from results at 24 h for CLSI and Etest methods only.

  • b Two strains of C. lusitaniae, one strain of C. guilliermondii, one strain of C. kefyr, and one strain of C. dubliniensis.

  • c Interpretative values and errors based on Vitek 2 expert software expertise.