TABLE 3.

Amphotericin B susceptibilities of the 205 Candida sp. isolates used in this study

Species (no. of isolates) and method% of isolates (48 h) with MIC (mg/liter) of:24 h48 hEAa (%)
≤1>1MIC rangeMIC50MIC90MIC rangeMIC50MIC90
C. albicans (84)
    VK2100≤0.25-1c0.51
    CLSI98.81.20.125-10.50.50.25-21198.8
    Etest1000.094-0.380.0940.190.016-0.50.1250.2529.8
C. parapsilosis (22)
    VK2100≤0.25-10.50.5
    CLSI81.818.20.125-0.50.250.50.5-21286.4
    Etest1000.094-0.50.1250.250.064-10.380.7563.6
C. tropicalis (17)
    VK2100≤0.25-0.50.50.5
    CLSI1000.5-10.2510.5-212100
    Etest1000.047-0.250.1250.190.032-0.750.250.570.6
Other Candida spp. (5)b
    VK2100≤0.25-0.50.50.5
    CLSI1000.06-10.50.50.25-10.50.5100
    Etest1000.047-0.380.250.25100
C. glabrata (56)
    VK294.65.4≤0.25-80.51
    CLSI89.310.70.125-20.510.25-21198.2
    Etest98.21.80.016-10.250.50.023->320.380.7573.2
C. inconspicua (5), C. norvegensis (2)
    VK2100≤0.25-1≤0.25≤0.25
    CLSI1000.03-10.1250.1250.25-10.250.25100
    Etest1000.016-0.750.0640.064100
C. krusei (14)
    VK292.97.10.5-20.51
    CLSI71.428.61-2120.25-212100
    Etest85.714.30.094-10.750.750.19-20.875278.6
  • a EA between VK2 and the two other methods at 48 h.

  • b C. lusitaniae (n = 2), C. guilliermondii (n = 1), C. kefyr (n = 1), and C. dubliniensis (n = 1).

  • c MICs are in micrograms per milliliter.