TABLE 1.

Fluconazole and voriconazole MIC50s and MIC90s obtained with VK2, CLSI (24 h and 48 h), and Etest (24 h and 48 h)

Candida sp. (no. of isolates), azole, and method24 h48 hEAa (%)
MIC rangeMIC50MIC90MIC rangeMIC50MIC90
C. albicans (84)
    Fluconazole
        VK2≤1-≥64d≤1≤1
        CLSI<0.125-640.1250.5<0.125->640.5298.8
        Etest0.094-1280.250.380.094->2560.625289.3
    Voriconazole
        VK2≤0.12-0.5≤0.12≤0.12
        CLSI<0.03-10.030.125<0.03-20.030.125100
        Etest0.003-10.0080.0230.002-20.020.06498.8
C. parapsilosis (22)
    Fluconazole
        VK2≤1≤1≤1
        CLSI<0.125-80.1250.5<0.125-80.250.595.4
        Etest0.064-0.50.3150.380.064-811.590.9
    Voriconazole
        VK2≤0.12≤0.12≤0.12
        CLSI<0.03-0.25<0.03<0.03<0.03-0.25<0.030.03100
        Etest0.004-0.0470.0120.0230.006-0.190.0320.064100
C. tropicalis (17)
    Fluconazole
        VK2≤1-2≤12
        CLSI<0.125-20.250.50.125-20.52100
        Etest0.5-21.51.50.38-61.5364.7
    Voriconazole
        VK2≤0.12≤0.12≤0.12
        CLSI<0.03-0.060.030.060.03-0.250.060.125100
        Etest0.016-0.0940.0470.0940.012-0.250.0940.19100
Other Candida spp. (5)c
    Fluconazole
        VK2≤1-2≤1≤1
        CLSI<0.125-0.50.1250.125<0.125-40.1250.125100
        Etest0.064-30.750.750.064-30.750.75100
    Voriconazole
        VK2≤0.12-≤0.12≤0.12≤0.12
        CLSI<0.03-<0.03<0.03<0.03<0.03-<0.03<0.003<0.003100
        Etest0.004-0.0940.0230.0230.004-0.0940.0230.023100
C. glabrata (56)
    Fluconazole
        VK2≤1-≥64832
        CLSI<0.125-64280.125->6461694.6
        Etest0.094->2567160.094->256>256>25625
    Voriconazole
        VK2≤0.12-≥8≤0.122
        CLSI<0.03-80.1250.50.03-80.125289.3
        Etest0.016-80.1251.50.032->321.53232.1
C. inconspicua (5), C. norvegensis (2)
    Fluconazole
        VK24-≥641616
        CLSI<0.125-16<0.125<0.1252-321616100
        Etest8-24101024->256>256>25685.7
    Voriconazole
        VK2≤0.12-0.25≤0.12≤0.12
        CLSI<0.03-0.5<0.03<0.030.03-0.50.250.25100
        Etest0.19-20.190.190.19-20.190.1985.7
C. krusei (14)
    Fluconazole
        VK24-321632100/92.8b
        CLSI0.25-6416328-643264100b
        Etest32->256>256>256
    Voriconazole
        VK2≤0.12-0.25≤0.120.25
        CLSI0.03-0.50.250.50.25-10.5192.8
        Etest0.19-0.50.250.250.064-1.50.251.564.3
  • a EA between VK2 and the two other methods at 48 h.

  • b EA calculated with Vitek 2 expert software interpretive values.

  • c C. lusitaniae (n = 2), C. guilliermondii (n = 1), C. kefyr (n = 1), and C. dubliniensis (n = 1).

  • d MICs are in micrograms per milliliter.