TABLE 1.

In vitro susceptibilities of Candida spp. and C. neoformans isolates to seven antifungal agents (SENTRY Program, 2003)

Species (no. of isolates tested) and drugMIC (μg/ml)% of isolatesa
50%90%RangeSusceptibleSDDResistant
All Candida spp. (1,397)
    Amphotericin B110.25-2
    5-FCb0.121≤0.03->6495.3(1.4)3.3
    Fluconazole0.516≤0.12-25688.57.34.2
    Ketoconazole0.031≤0.008-4
    Itraconazole0.121≤0.008->1655.628.915.5
    Voriconazole0.0160.25≤0.008-8
    Ravuconazole0.0160.25≤0.008-4
C. albicans (680)
    Amphotericin B110.25-2
    5-FC0.122≤0.03->6497.8(0.4)1.8
    Fluconazole≤0.250.5≤0.12-12899.40.10.4
    Ketoconazole≤0.0080.016≤0.008-2
    Itraconazole0.060.12≤0.008-292.86.90.3
    Voriconazole≤0.008≤0.008≤0.008-4
    Ravuconazole≤0.008≤0.008≤0.008-4
C. parapsilosis (242)
    Amphotericin B110.5-2
    5-FC0.120.5≤0.03-2100.0(0.0)0.0
    Fluconazole120.25-6498.80.80.4
    Ketoconazole0.120.250.016-1
    Itraconazole0.250.50.03-132.665.71.7
    Voriconazole0.030.12≤0.008-1
    Ravuconazole0.030.12≤0.008-0.5
C. glabrata (240)
    Amphotericin B110.25-2
    5-FC0.060.12≤0.03-2100.0(0.0)0.0
    Fluconazole8641-12852.135.812.1
    Ketoconazole0.520.12-4
    Itraconazole120.25->160.026.373.7
    Voriconazole0.2510.03-4
    Ravuconazole0.2510.03-4
C. tropicalis (152)
    Amphotericin B110.5-2
    5-FC0.251≤0.03->6490.1(0.7)9.2
    Fluconazole12≤0.12-12898.00.71.3
    Ketoconazole0.030.12≤0.008-4
    Itraconazole0.250.50.016-232.264.53.3
    Voriconazole0.060.12≤0.008-8
    Ravuconazole0.030.12≤0.008-4
C. krusei (27)
    Amphotericin B121-2
    5-FC32648->640.0(44.4)55.6
    Fluconazole6412816-2560.025.974.1
    Ketoconazole120.5-4
    Itraconazole110.25-20.040.759.3
    Voriconazole0.50.50.12-4
    Ravuconazole0.50.50.12-2
Candida spp. (56)
    Amphotericin B110.25-2
    5-FC0.1216≤0.03->6483.9(7.2)8.9
    Fluconazole0.1216≤0.12-12883.910.75.4
    Ketoconazole0.120.5≤0.008-2
    Itraconazole0.2510.03-232.146.521.4
    Voriconazole0.030.25≤0.008-1
    Ravuconazole0.030.5≤0.008-1
C. neoformans (53)c
    Amphotericin B110.25-2
    5-FC8162-16
    Fluconazole16324-64
    Ketoconazole0.510.12-1
    Itraconazole0.510.25-1
    Voriconazole0.120.50.03-0.5
    Ravuconazole0.120.50.016-0.5
  • a The breakpoint criteria are those of the NCCLS/CLSI (7). Numbers in parentheses indicate the percent intermediate, not the susceptibility dose dependent (SDD) (7).

  • b 5-FC, 5-fluorocytosine.

  • c Breakpoint criteria have not been established for cryptococcal organisms.