TABLE 3.

Activities of six antifungal agents to A. fumigatus and other Aspergillus spp. (SENTRY Program, 2003)

Species (no. of isolates tested) and drugMIC (μg/ml)% Inhibited at ≤1 μg/mla
50%90%Range
A. fumigatus (52)
    Amphotericin B241-1611.5
    Fluconazole256>25664->256
    Ketoconazole480.5-8
    Itraconazole120.25-284.6
    Voriconazole0.510.12-296.2
    Ravuconazole0.510.12-296.2
Other Aspergillus spp. (21)
    Amphotericin B241-49.5
    Fluconazole256>25664->256
    Ketoconazole280.5-8
    Itraconazole120.5-271.4
    Voriconazole0.520.06-481.0
    Ravuconazole120.25-476.2
  • a Breakpoint criteria have not been established by the CLSI; for comparison purposes, a susceptible breakpoint only was used at ≤1 μg/ml (8, 17).