TABLE 5.

In vitro activity of amphotericin B, fluconazole, and flucytosine against Norwegian candidemia isolates

SpeciesAntifungal agent (no. of isolates)MIC range (μg/ml)MIC50 (μg/ml)MIC90 (μg/ml)
C. albicansAmphotericin B (934)0.06-20.51
Fluconazole (934)0.25-40.51
Flucytosine (734)0.06-640.1250.5
C. glabrataAmphotericin B (180)0.06-20.51
Fluconazole (180)1-641664
Flucytosine (138)0.06-320.1250.25
C. tropicalisAmphotericin B (93)0.06-10.51
Fluconazole (93)0.5-6414
Flucytosine (81)0.06-640.1250.5
C. parapsilosisAmphotericin B (82)0.06-10.51
Fluconazole (82)0.25-1612
Flucytosine (69)0.125-10.1250.25
C. kruseiAmphotericin B (22)0.25-212
Fluconazole (22)32-646464
Flucytosine (17)16-321632
OtheraAmphotericin B (37)0.06-10.51
Fluconazole (37)0.25-640.564
Flucytosine (26)0.06-640.2516
All isolatesAmphotericin B (1,348)0.06-20.51
Fluconazole (1,348)0.25-640.516
Flucytosine (1,065)0.06-640.1250.5
  • a Other species include C. blankii, C. dubliniensis, C. guilliermondii, C. kefyr, C. lusitaniae, C. norvegensis, C. sake, and C. sphaerica.