TABLE 4.

Presence or absence/divergence for select adhesins, exoenzymes, exotoxins, and regulatory elements in CMRSA1 to CMRSA10

Locus tagGeneDescriptionPresence or absence/divergence in strain:
CMRSA1CMRSA2CMRSA3CMRSA4CMRSA5CMRSA6CMRSA7CMRSA8CMRSA9CMRSA10
Adhesins
    SACOL0608sdrCSdrC protein++++++++
    SACOL0609sdrDSdrD protein+/−++++++++
    SACOL0610sdrESdrE protein++++++++++
    SACOL1169fibFibrinogen-binding protein precursor-related protein+++++++
    SACOL2509fnbBFibronectin-binding protein B++++++++
    SACOL2511fnbAFibronectin-binding protein A++/−+++++
Exoenzymes
    SACOL1864Serine protease SplF++++++++
    SACOL1865Serine protease SplE++++++
    SACOL1866Serine protease SplD+++++++
    SACOL1867Serine protease SplC+++/−+++++
    SACOL1868Serine protease SplB+++++++
    SACOL1869Serine protease SplA+++++++
    SACOL1871epiGEpidermin immunity protein− (−)− (−)+ (+)− (−)+ (+)+ (+)+ (+)− (−)+ (+)+ (+)
    SACOL1872epiEEpidermin immunity protein− (−)− (−)+ (+)− (−)+ (+)+ (+)+ (+)− (−)+ (+)+ (+)
    SACOL1873epiFEpidermin immunity protein++++++
    SACOL1874epiPEpidermin leader peptide-processing serine protease− (−)− (−)+ (+)− (−)+ (+)+ (+)+ (+)− (−)+ (+)+ (+)
    SACOL1875epiDEpidermin biosynthesis protein++++++
    SACOL1876epiCEpidermin biosynthesis protein− (−)− (−)+ (+)− (−)+ (+)+ (+)+ (+)− (−)+ (+)+ (+)
    SACOL1877epiBEpidermin biosynthesis protein++++++
    SACOL1878epiALantibiotic epidermin precursor++++++
    SACOL2659aurAureolysin+/−++++/−++++
Exotoxins
    SACOL0265Diarrheal toxin-like protein+/−+/−++++++++
    SACOL0468Exotoxin 3+/−+/−+++++
    SACOL0469Exotoxin 2+/−+/−+/−+/−++++
    SACOL0470Exotoxin 2+/−+/−+/−+/−+++++
    SACOL0472Exotoxin 2+++++++
    SACOL0473Exotoxin 5++++++++
    SACOL0474Exotoxin 4+/−+/−+/−+/−+/−+/−++
    SACOL0478Exotoxin 3+++++
    SACOL0762“Hemolysin, putative”++++++++++
    SACOL0886sekStaphylococcal enterotoxin− (−)− (−)+ (+)− (−)+ (+)+ (+)+ (+)− (−)− (−)+ (+)
    SACOL0887seiStaphylococcal enterotoxin type I− (−)− (−)+ (+)− (−)+ (+)+ (+)+ (+)− (−)− (−)+ (+)
    SACOL0907sebStaphylococcal enterotoxin B++
    SACOL1178“Exotoxin 1, putative”+++++++
    SACOL1179“Exotoxin 4, putative”+++++++
    SACOL1180“Exotoxin 3, putative”++++++++
    SACOL1880lukDLeukotoxin LukD+++++++
    SACOL1881lukSSynergohymenotropic toxin LukS+++++++
    SACOL2004lukF“Leukocidin precursor, F subunit, putative”+++++++++
    SACOL2006lukMLeukotoxin LukM++++++++
    SACOL2160“Hemolysin, putative”+++++++++
Regulatory
    SACOL0072“Transcriptional regulator, LysR family”++++++
    SACOL0074“Transcriptional regulator, LysR family”+++++
    SACOL0091“Transcriptional regulator, GntR family”+++++
    SACOL0672sarAStaphylococcal accessory regulator A+/−+/−++++++++
    SACOL1891RNA III-activating protein TRAP+++++++
    SACOL2023agrBAccessory gene regulator protein B++++++++
    SACOL2506sarTStaphylococcal accessory regulator T++++++++
    SACOL2507sarUStaphylococcal accessory regulator U− (−)+ (+)+ (+)− (−)+ (+)+ (+)+ (+)+ (+)+ (+)+ (+)
    SACOL2524“Transcriptional regulator, MarR family”++++++
Other
    SACOL0046Metallo-beta-lactamase family protein− (−)− (−)− (−)− (−)− (−)− (−)+ (+)− (−)− (−)+ (+)
    SACOL0143cap5HCapsular polysaccharide biosynthesis protein− (−)+/− (+)+ (−)− (−)+ (+)− (−)− (−)+ (+)+ (+)+ (+)
    SACOL0144cap5ICapsular polysaccharide biosynthesis protein− (−)+/− (+)+ (−)+/− (−)+ (+)− (−)− (−)+ (+)+ (+)+ (+)
    SACOL0145cap5JCapsular polysaccharide biosynthesis protein− (−)+/− (+)− (−)+ (−)+ (+)− (−)− (−)+ (+)+ (+)+ (+)
    SACOL2196Hypothetical protein+ (+)+ (+)+ (+)+ (+)+ (+)+ (+)− (−)+ (+)+ (+)+ (+)
  • a+, presence of gene; −, absence of gene; +/−, unknown. PCR results are shown in parentheses: +, positive PCR amplicon; −, negative PCR amplicon.